Comparative proteomic analysis of membranous nephropathy biopsy tissues using quantitative proteomics
نویسندگان
چکیده
منابع مشابه
Comparative proteomic analysis of membranous nephropathy biopsy tissues using quantitative proteomics
Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults and the second leading cause of end-stage renal disease due to primary glomerulonephritis. The aim of the present study was to identify potential biomarkers of MN and further characterize these proteins by Gene Ontology (GO) analysis. Isobaric tags for relative and absolute quantification were used to compare the prot...
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A forty-three year old female applied for a $200,000 ten year decreasing term policy. She admitted a history of "kidney disorder" on the application. She was not being treated or having any symptoms but stated that she was under observation. A routine paramed exam showed height 5’4", weight 140 lbs, and blood pressure 110/70. The BCP was normal. The HOS showed 210 mg/dl proteinuria. A reflex de...
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Forty-one patients with a nephrotic syndrome and biopsy-proven membranous nephropathy were administered a 3 to 6-month course of cyclosporine (CsA; 4 to 5 mg/kg per day). Differential solute clearances were used to evaluate glomerular function before and after therapy. CsA lowered median proteinuria by 56%, from 7.3 to 3.2 g/24 h (P < 0.0001). Corresponding mean increments in serum albumin, imm...
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Membranous nephropathy (MN), a very common cause of nephrotic syndrome, is a glomerulopathy defined histopathologically by the presence of immune complexes on the extracapillary side of the glomerular basement membrane (GBM). Idiopathic membranous nephropathy (IMN) is an antibody-mediated glomerular disease with no defined etiology, histologically characterized by uniform thickening of glomerul...
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The management of membranous nephropathy first requires the recognition of whether the disorder is primary (idiopathic) or secondary. Next, a familiarity with its natural history and knowledge of our current capacity to predict those patients with the worst outcome is reviewed. Treatment options of those at risk of progression with immunosuppressive drugs is then discussed along with the requir...
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ژورنال
عنوان ژورنال: Experimental and Therapeutic Medicine
سال: 2015
ISSN: 1792-0981,1792-1015
DOI: 10.3892/etm.2015.2197